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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311750
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mettl3
Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
Acc ID: CHEBI:37943
Term: colistin
Definition: A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.
Chemical ID: MESH:D003091
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mettl3decreases expressionISOMettl3 (Mus musculus)6480464CTDColistin results in decreased expression of METTL3 mRNA; Colistin results in decreased expression of METTL3 proteinPMID:34560125
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