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GENE - TERM ANNOTATION REPORT

RGD ID: 1311278
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sel1l2
Name: SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase
Acc ID: GO:0036503
Term: ERAD pathway
Definition: The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Definition Source(s): GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sel1l2involved_inIBAMGI:1329016 or PANTHER:PTN000121233 or UniProtKB:Q9UBV21600115GO_CentralGO_REF:0000033

GO_REF:0000033
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