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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mgst2
Name: microsomal glutathione S-transferase 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgst2affects methylationISOMGST2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of MGST2 intronPMID:30157460
Mgst2decreases expressionISOMGST2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of MGST2 mRNAPMID:26238291
Mgst2decreases expressionISOMgst2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of MGST2 mRNAPMID:20127859
Mgst2increases expressionISOMGST2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of MGST2 mRNAPMID:16545412
Mgst2increases expressionISOMgst2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of MGST2 mRNAPMID:20713471 PMID:25908611
Mgst2increases methylationISOMGST2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of MGST2 promoterPMID:27901495
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