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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310908
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nt5c1a
Name: 5'-nucleotidase, cytosolic IA
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nt5c1adecreases response to substanceISONt5c1a (Mus musculus)6480464CTDNT5C1A protein results in decreased susceptibility to FluorouracilPMID:16362297
Nt5c1amultiple interactionsISONt5c1a (Mus musculus)6480464CTDNT5C1A protein results in decreased susceptibility to [Fluorouracil co-treated with Cladribine]PMID:16362297
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