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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310836
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptges2
Name: prostaglandin E synthase 2
Acc ID: CHEBI:3435
Term: carrageenan
Definition: A family of sulfated polysaccharides extracted from red seaweeds. The name is derived from a common name of red algae Chondrus crispus, 'carrageen moss' (Irish moss).
Chemical ID: MESH:D002351
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptges2increases activityEXP 6480464CTDCarrageenan results in increased activity of PTGES2 proteinPMID:19934399
Ptges2multiple interactionsEXP 6480464CTD2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid inhibits the reaction [[Carrageenan results in increased activity of PTGES2 protein] which results in increased chemical synthesis of Dinoprostone]; [Carrageenan results in increased activity of PTGES2 protein] which results in increased chemical synthesis of DinoprostonePMID:19934399
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