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GENE - TERM ANNOTATION REPORT

RGD ID: 1309725
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dvl2
Name: dishevelled segment polarity protein 2
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dvl2acts_upstream_of_or_withinISODvl2 (Mus musculus)1624291RGDMGI:1351660 PMID:17606995

PMID:17606995
Dvl2involved_inISODVL2 (Homo sapiens)1624291RGD PMID:17593335 PMID:18787224

PMID:17593335 PMID:18787224
Dvl2involved_inISODvl2 (Mus musculus)1624291RGDMGI:2429760 MGI:98956 MGI:5285137 PMID:21189423 MGI:5700301 PMID:18093802 PMID:10409711 PMID:18606138 PMID:19008950 PMID:8887313

MGI:5285137 MGI:5700301 PMID:10409711 PMID:18093802 PMID:18606138 PMID:19008950 PMID:21189423 PMID:8887313
Dvl2involved_inIBAFB:FBgn0000499 or MGI:106613 or MGI:108100 or MGI:2679721 or MGI:94941 or PANTHER:PTN000093945 or UniProtKB:O14640 or UniProtKB:O14641 or UniProtKB:Q155Q3 or UniProtKB:Q92997 or ZFIN:ZDB-GENE-010319-1 or ZFIN:ZDB-GENE-030721-21600115GO_CentralGO_REF:0000033

GO_REF:0000033
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