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GENE - TERM ANNOTATION REPORT

RGD ID: 1308731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Zbtb37
Name: zinc finger and BTB domain containing 37
Acc ID: DOID:6688
Term: autoimmune lymphoproliferative syndrome
Definition: A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen. (DO)
Definition Source(s): http://ghr.nlm.nih.gov/condition/autoimmune-lymphoproliferative-syndrome "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Zbtb37 ISOZBTB37 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE I, AUTOSOMAL DOMINANTPMID:22857792 PMID:25451160 PMID:28492532
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