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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:35546
Term: perfluorodecanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated decanoic acid.
Chemical ID: MESH:C036567
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3multiple interactionsISONLRP3 (Homo sapiens)6480464CTDNLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of FASN mRNA]; NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of HMGCS1 mRNA]; NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of SCD mRNA]PMID:36423729
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