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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3increases expressionEXP 6480464CTDlead acetate results in increased expression of NLRP3 mRNAPMID:37471654
Nlrp3multiple interactionsEXP 6480464CTDsinapinic acid inhibits the reaction [lead acetate results in increased expression of NLRP3 mRNA]PMID:37471654
Nlrp3multiple interactionsISONlrp3 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NLRP3 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of NLRP3 protein; NLRP3 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL1B protein]; NLRP3 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL6 protein]; NLRP3 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of TNF protein]; NLRP3 gene mutant form results in decreased susceptibility to [lead acetate results in increased abundance of Lead]PMID:36308466
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