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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:30614
Term: benzo[a]pyrene diol epoxide I
Definition: An epoxide that has formula C20H14O3.
Chemical ID: MESH:D015123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3increases expressionISONLRP3 (Homo sapiens)6480464CTD7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NLRP3 proteinPMID:35297523
Nlrp3multiple interactionsISONLRP3 (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NLRP3 protein]PMID:35297523
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