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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3increases expressionISONlrp3 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of NLRP3 proteinPMID:27477297 PMID:35405287
Nlrp3multiple interactionsISONlrp3 (Mus musculus)6480464CTDNFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]; Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]PMID:27477297 PMID:35405287
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