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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3increases expressionISONlrp3 (Mus musculus)6480464CTDTrichloroethylene results in increased expression of NLRP3 mRNAPMID:36849104
Nlrp3multiple interactionsISONlrp3 (Mus musculus)6480464CTDSirolimus inhibits the reaction [Trichloroethylene results in increased expression of NLRP3 mRNA]PMID:36849104
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