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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:15771
Term: loganin
Definition: An iridoid monoterpenoid with formula C17H26O10 that is isolated from several plant species and exhibits neuroprotective and anti-inflammatory properties.
Chemical ID: MESH:C059516
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3multiple interactionsISONLRP3 (Homo sapiens)6480464CTDloganin inhibits the reaction [Glucose results in increased expression of NLRP3 mRNA]; loganin inhibits the reaction [Glucose results in increased expression of NLRP3 protein]PMID:37473909
Nlrp3multiple interactionsISONlrp3 (Mus musculus)6480464CTDloganin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of NLRP3 mRNA]; loganin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of NLRP3 protein]PMID:37473909
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