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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308277
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1b10
Name: aldo-keto reductase family 1 member B10
Acc ID: CHEBI:18009
Term: NADP(+)
Definition: A NAD(P)(+) that has formula C21H29N7O17P3.
Chemical ID: MESH:D009249
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b10affects bindingISOAKR1B10 (Homo sapiens)6480464CTDNADP binds to AKR1B10 protein mutant form binds to fidarestatPMID:23295227
Akr1b10decreases reductionISOAKR1B10 (Homo sapiens)6480464CTDAKR1B10 protein results in decreased reduction of NADPPMID:19013440
Akr1b10increases activityISOAKR1B10 (Homo sapiens)6480464CTDNADP results in increased activity of AKR1B10 proteinPMID:23295224
Akr1b10multiple interactionsISOAKR1B10 (Homo sapiens)6480464CTD[AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde; [AKR1B10 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol; [AKR1B10 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dionePMID:17329238 PMID:21910479
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