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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sphk2
Name: sphingosine kinase 2
Acc ID: CHEBI:63112
Term: fingolimod hydrochloride
Definition: The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).
Chemical ID: MESH:D000068876
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sphk2increases phosphorylationISOSPHK2 (Homo sapiens)6480464CTDSPHK2 protein results in increased phosphorylation of Fingolimod HydrochloridePMID:24859201
Sphk2increases response to substanceISOSphk2 (Mus musculus)6480464CTDSPHK2 results in increased susceptibility to Fingolimod HydrochloridePMID:23043544
Sphk2multiple interactionsISOSPHK2 (Homo sapiens)6480464CTDFingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]PMID:24859201
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