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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306888
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2
Name: nuclear factor, erythroid 2
Acc ID: CHEBI:74619
Term: aclacinomycin A
Definition: An anthracycline antibiotic that is produced by Streptomyces galilaeus and also has potent antineoplastic activity.
Chemical ID: MESH:D015250
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2increases expressionISONFE2 (Homo sapiens)6480464CTDAclarubicin results in increased expression of NFE2 mRNAPMID:10656287
Nfe2multiple interactionsISONFE2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]PMID:10656287
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