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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306888
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2
Name: nuclear factor, erythroid 2
Acc ID: CHEBI:50385
Term: hemin
Definition: It is used as a prescription medication to relieve repeated attacks of acute intermittent porphyria related to the menstrual cycle in affected women.
Chemical ID: MESH:D006427
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2increases expressionISONFE2 (Homo sapiens)6480464CTDHemin results in increased expression of NFE2 mRNAPMID:21414390 PMID:28552822
Nfe2multiple interactionsISONFE2 (Homo sapiens)6480464CTDcatechol promotes the reaction [Hemin results in increased expression of NFE2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of NFE2 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]PMID:21414390 PMID:28552822
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