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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306305
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tjp1
Name: tight junction protein 1
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tjp1affects localizationISOTJP1 (Homo sapiens)6480464CTDdeoxynivalenol affects the localization of TJP1 proteinPMID:24568843
Tjp1decreases expressionISOTjp1 (Mus musculus)6480464CTDdeoxynivalenol results in decreased expression of TJP1 mRNA; deoxynivalenol results in decreased expression of TJP1 proteinPMID:34506767 PMID:35381244 PMID:35817260
Tjp1increases expressionISOTJP1 (Homo sapiens)6480464CTDdeoxynivalenol results in increased expression of TJP1 mRNAPMID:24568843
Tjp1increases expressionISOTjp1 (Mus musculus)6480464CTDdeoxynivalenol results in increased expression of TJP1 mRNAPMID:24568843
Tjp1multiple interactionsISOTjp1 (Mus musculus)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]]; 6-formylindolo(3,2-b)carbazole inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]]; 6-formylindolo(3,2-b)carbazole inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 protein]]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of and affects the localization of TJP1 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]; deoxynivalenol results in decreased expression of and affects the localization of TJP1 protein; lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 protein]; sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]; sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 protein]PMID:34506767 PMID:35381244 PMID:35817260
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