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GENE - TERM ANNOTATION REPORT

RGD ID: 1305907
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Taf10
Name: TATA-box binding protein associated factor 10
Acc ID: GO:0000124
Term: SAGA complex
Definition: A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).
Definition Source(s): PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Taf10part_ofISOTAF10 (Homo sapiens)1624291RGD PMID:11564863 PMID:9674425

PMID:11564863 PMID:9674425
Taf10part_ofIBAFB:FBgn0026324 or PANTHER:PTN000478466 or PomBase:SPBC21H7.02 or SGD:S000002574 or UniProtKB:Q12962 or UniProtKB:Q5BH261600115GO_CentralGO_REF:0000033

GO_REF:0000033
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