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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm2
Name: MDM2 proto-oncogene
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2increases expressionEXP 6480464CTDPhenobarbital results in increased expression of MDM2 mRNAPMID:25145657
Mdm2increases expressionISOMdm2 (Mus musculus)6480464CTDPhenobarbital results in increased expression of MDM2 mRNAPMID:19482888 PMID:20816995 PMID:25145657
Mdm2increases phosphorylationISOMDM2 (Homo sapiens)6480464CTDPhenobarbital results in increased phosphorylation of MDM2 proteinPMID:19751709
Mdm2multiple interactionsISOMdm2 (Mus musculus)6480464CTDNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MDM2 mRNA]; NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of MDM2 mRNA]PMID:19482888
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