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GENE - TERM ANNOTATION REPORT

RGD ID: 1305278
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adam33
Name: ADAM metallopeptidase domain 33
Acc ID: DOID:2841
Term: asthma
Definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. (DO)
Definition Source(s): http://www.nhlbi.nih.gov/health/dci/Diseases/Asthma/Asthma_WhatIs.html "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK430901/ "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK7223/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adam33 ISOADAM33 (Homo sapiens)4145359RGDDNA:SNPs (human) 
Adam33 ISOAdam33 (Mus musculus)4145360RGDmRNA:increased expression:lung 
Adam33disease_progressionISOADAM33 (Homo sapiens)4145380RGDmRNA:increased expression:bronchus 
Adam33no_associationISOADAM33 (Homo sapiens)4145382RGDDNA:SNPs:introns,exon:7575G>A, 11188A>T, 12433T>C (human) 
Adam33susceptibilityISOADAM33 (Homo sapiens)4145378RGDDNA:SNPs: :multiple (human) 
Adam33susceptibilityISOADAM33 (Homo sapiens)4145379RGDDNA:polymorphism: :p.M764T (human) 
Adam33 ISOADAM33 (Homo sapiens)1331525GAD  
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