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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305144
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb2
Name: ribosomal protein S6 kinase B2
Acc ID: CHEBI:16337
Term: phosphatidic acid
Definition: A derivative of glycerol in which one hydroxy group, commonly but not necessarily primary, is esterified with phosphoric acid and the other two are esterified with fatty acids.
Chemical ID: MESH:D010712
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb2increases activityISORPS6KB2 (Homo sapiens)6480464CTDPhosphatidic Acids results in increased activity of RPS6KB2 proteinPMID:12087098
Rps6kb2multiple interactionsISORPS6KB2 (Homo sapiens)6480464CTDMTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]; Sirolimus inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]; wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]PMID:12087098
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