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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304709
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Car8
Name: carbonic anhydrase 8
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Car8decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CA8 mRNA; bisphenol A results in decreased expression of CAR8 mRNAPMID:22504913 PMID:25181051
Car8increases expressionEXP 6480464CTDbisphenol A results in increased expression of CA8 mRNA; bisphenol A results in increased expression of CAR8 mRNAPMID:32145629 PMID:34947998
Car8increases methylationEXP 6480464CTDbisphenol A results in increased methylation of CAR8 genePMID:28505145
Car8multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Testosterone] results in decreased expression of CAR8 mRNAPMID:26496021
Car8decreases expressionISOCA8 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CA8 mRNAPMID:27685785
Car8increases expressionISOCar8 (Mus musculus)6480464CTDbisphenol A results in increased expression of CAR8 mRNAPMID:32156529
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