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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco4c1affects methylationISOSLCO4C1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SLCO4C1 3' UTR; Benzo(a)pyrene affects the methylation of SLCO4C1 promoterPMID:27901495
Slco4c1decreases expressionISOSLCO4C1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of SLCO4C1 mRNAPMID:20064835 PMID:20106945 PMID:21632981 PMID:26238291 PMID:32234424
Slco4c1decreases expressionISOSlco4c1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SLCO4C1 mRNAPMID:19770486 PMID:21715664
Slco4c1increases methylationISOSLCO4C1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SLCO4C1 exonPMID:27901495
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