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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11295
Species: Mus musculus
RGD Object: Gene
Symbol: Slc10a1
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc10a1decreases expressionEXP 6480464CTDLithocholic Acid results in decreased expression of SLC10A1 mRNA; Lithocholic Acid results in decreased expression of SLC10A1 proteinPMID:12637555 PMID:16436656 PMID:17256725 PMID:20977460 PMID:23034213 PMID:25582706
Slc10a1multiple interactionsEXP 6480464CTD[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of SLC10A1 mRNA; NR1H3 protein inhibits the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]PMID:17256725 PMID:18032408 PMID:23034213
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