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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11217
Species: Mus musculus
RGD Object: Gene
Symbol: Rarb
Name: retinoic acid receptor, beta
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rarbdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of RARB mRNAPMID:19770486
Rarbincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of RARB mRNAPMID:22228805
Rarbmultiple interactionsEXP 6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of RARB mRNA]PMID:22228805
Rarbaffects methylationISORARB (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of RARB 5' UTR; Benzo(a)pyrene affects the methylation of RARB intronPMID:27901495 PMID:30157460
Rarbdecreases expressionISORarb (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of RARB proteinPMID:21467743
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