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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10694
Species: Mus musculus
RGD Object: Gene
Symbol: Gss
Name: glutathione synthetase
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gssaffects expressionISOGSS (Homo sapiens)6480464CTDLithocholic Acid affects the expression of GSS mRNA; Lithocholic Acid affects the expression of GSS proteinPMID:20146260
Gssmultiple interactionsISOGSS (Homo sapiens)6480464CTDS-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]PMID:20146260
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