NICOTINAMIDE ADENINE DINUCLEOTIDE BIOSYNTHETIC PATHWAY (PW:0000219)

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Description

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme of enzyme-catalyzed reduction-oxidation (redox) reactions. Its discovery and mechanistic understanding span more than a century and brought four Nobel prizes. NAD+ and its reduced form NADH, and the phosphorylated NADP/NADPH forms, serve as hydride acceptors or donors in over 2,000 redox reactions. In addition to its known role as a cofactor in redox reactions, NAD+ serves as a substrate for several classes of enzymes that include

Pathway Diagram:

Elsevier Inc. NAD consuming enzymes nicotinamide adenine dinucleotide utilization pathway nicotinamide ---> nicotinamide mononucleotide nicotinamide riboside ---> nicotinamide mononucleotide nicotinic acid ---> nicotinic acid mononucleotide quinolinic acid ---> nicotinic acid mononucleotide Nmnat1 Nmnat2 Nmnat3 Nmrk2 Nampt Nmrk1 Nadsyn1 Qprt Naprt1 diet nicotinamide mononucleotide ---> NAD+ nicotinic acid mononucleotide ---> nicotinic acid adenine dinucleotide NAD+ ---> nicotinamide nicotinamide ---| Sirtuins quinolinic acid nicotinic acid nicotinamide riboside nicotinamide nicotinamide mononucleotide nicotinic acid mononucleotide NAD+ nicotinic acid adenine dinucleotide kynurenine metabolic pathway Sirtuins PARPs nicotinic acid adenine dinucleotide ---> NAD+ diet ---> nicotinic acid kynurenine metabolic pathway ---> quinolinic acid diet ---> nicotinamide riboside
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de novo nicotinamide adenine dinucleotide biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nadsyn1 NAD synthetase 1 JBrowse link 1 216,985,710 217,013,743 RGD:11099972
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 JBrowse link 5 166,409,460 166,430,291 RGD:11099972
G Nmnat2 nicotinamide nucleotide adenylyltransferase 2 JBrowse link 13 70,379,346 70,559,311 RGD:11099972
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 JBrowse link 8 106,317,038 106,429,535 RGD:11099972
G Qprt quinolinate phosphoribosyltransferase JBrowse link 1 198,544,262 198,559,556 RGD:11099972
nicotinamide adenine dinucleotide biosynthesis, the salvage pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nadsyn1 NAD synthetase 1 JBrowse link 1 216,985,710 217,013,743 RGD:11099972
G Nampt nicotinamide phosphoribosyltransferase JBrowse link 6 52,122,085 52,156,473 RGD:11099972
G Naprt nicotinate phosphoribosyltransferase JBrowse link 7 116,922,979 116,926,436 RGD:11099972
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 JBrowse link 5 166,409,460 166,430,291 RGD:11099972
G Nmnat2 nicotinamide nucleotide adenylyltransferase 2 JBrowse link 13 70,379,346 70,559,311 RGD:11099972
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 JBrowse link 8 106,317,038 106,429,535 RGD:11099972
G Nmrk1 nicotinamide riboside kinase 1 JBrowse link 1 234,721,992 234,749,452 RGD:11099972
G Nmrk2 nicotinamide riboside kinase 2 JBrowse link 7 11,382,966 11,386,170 RGD:11099972

Pathway Gene Annotations

References Associated with the nicotinamide adenine dinucleotide biosynthetic pathway:

Ontology Path Diagram:

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