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Ontology Browser
Term:
siRNA-mediated gene silencing by mRNA destabilization (GO:0090625)
Annotations: Rat: (4) Mouse: (4) Human: (4) Chinchilla: (4) Bonobo: (4) Dog: (4) Squirrel: (2) Pig: (3) Naked Mole-rat: (4) Green Monkey: (4)
Parent Terms Term With Siblings Child Terms
3'-UTR-mediated mRNA destabilization  
miRNA-mediated gene silencing by mRNA destabilization  
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +   
piRNA-mediated gene silencing by mRNA destabilization +  
polyadenylation-dependent mRNA catabolic process +   
polyuridylation-dependent mRNA catabolic process +   
siRNA-mediated gene silencing by inhibition of translation 
siRNA-mediated gene silencing by mRNA destabilization +   
An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.

Synonyms
Exact Synonyms: mRNA cleavage involved in gene silencing by siRNA
Broad Synonyms: gene silencing by mRNA cleavage
Definition Sources: GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970

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