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Ontology Browser
Term:
miRNA-mediated gene silencing by mRNA destabilization (GO:0035279)
Annotations: Rat: (89) Mouse: (109) Human: (129) Chinchilla: (8) Bonobo: (8) Dog: (93) Squirrel: (7) Pig: (71) Naked Mole-rat: (8) Green Monkey: (8)
Parent Terms Term With Siblings Child Terms
3'-UTR-mediated mRNA destabilization  
miRNA-mediated gene silencing by inhibition of translation  
miRNA-mediated gene silencing by mRNA destabilization  
An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism.
negative regulation of miRNA-mediated gene silencing +   
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +   
piRNA-mediated gene silencing by mRNA destabilization +  
polyadenylation-dependent mRNA catabolic process +   
polyuridylation-dependent mRNA catabolic process +   
positive regulation of miRNA-mediated gene silencing +   
pre-miRNA export from nucleus  
regulation of miRNA-mediated gene silencing +   
siRNA-mediated gene silencing by mRNA destabilization +   

Synonyms
Exact Synonyms: gene silencing by miRNA, mRNA cleavage ;   mRNA cleavage involved in gene silencing by miRNA ;   mRNA cleavage involved in gene silencing by microRNA ;   miRNA-mediated gene silencing, mRNA cleavage
Broad Synonyms: gene silencing by mRNA cleavage
Related Synonyms: deadenylation involved in gene silencing by miRNA ;   miRNA-mediated gene silencing by mRNA deadenylation
Definition Sources: GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554, PMID:21118121, PMID:23209154

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