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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
heterochromatin formation +   
An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.
negative regulation of gene expression via chromosomal CpG island methylation  

Synonyms
Exact Synonyms: chromatin silencing ;   chromatin-mediated silencing ;   establishment of heterochromatin architecture ;   heterochromatin assembly
Narrow Synonyms: establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region ;   establishment of heterochromatin architecture involved in chromatin silencing at pericentric region ;   heterochromatin assembly involved in chromatin silencing at centromere outer repeat region ;   heterochromatin assembly involved in chromatin silencing at pericentric region ;   heterochromatin formation involved in chromatin silencing at centromere outer repeat region ;   heterochromatin formation involved in chromatin silencing at pericentric region
Broad Synonyms: TGS ;   heterochromatin maintenance
Related Synonyms: establishment of chromatin silencing ;   establishment of heterochromatic silencing ;   heterochromatic silencing ;   heterochromatin assembly involved in chromatin silencing ;   heterochromatin formation involved in chromatin silencing ;   transcriptional gene silencing
Alternate IDs: GO:0006342 ;   GO:0006343 ;   GO:0016440 ;   GO:0070869 ;   GO:1904497
Definition Sources: PMID:25192661, PMID:33827924

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