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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
Atg12 transferase activity +   
FAT10 transferase activity +  
ISG15 transferase activity +   
NEDD8 transferase activity +   
Pup transferase activity +  
SUMO transferase activity +   
ubiquitin-like protein conjugating enzyme activity +   
ubiquitin-like protein ligase activity +   
ubiquitin-protein transferase activity +   
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
UFM1 transferase activity +   
URM1 transferase activity +  

Synonyms
Related Synonyms: E2 ;   E3 ;   ubiquitin conjugating enzyme activity ;   ubiquitin ligase activity ;   ubiquitin protein ligase activity
Alternate IDs: GO:0004840 ;   GO:0004841
Xrefs: KEGG_REACTION:R03876 ;   Reactome:R-HSA-3797226 "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)" ;   Reactome:R-HSA-68712 "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1" ;   Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS" ;   Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation" ;   Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer" ;   Reactome:R-HSA-9688831 "STUB1 ubiquitinates RIPK3 at K55, K363" ;   Reactome:R-HSA-9701000 "BRCA1:BARD1 heterodimer autoubiquitinates" ;   Reactome:R-HSA-9750946 "TRAF2,6 ubiquitinates NLRC5" ;   Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex" ;   Reactome:R-HSA-9758604 "Ubiquitination of IKBKG by TRAF6" ;   Reactome:R-HSA-9793444 "ITCH polyubiquitinates MLKL at K50" ;   Reactome:R-HSA-9793485 "PRKN polyubiquitinates RIPK3" ;   Reactome:R-HSA-9793679 "LUBAC ubiquitinates RIPK1 at K627" ;   Reactome:R-HSA-9796346 "MIB2 ubiquitinates RIPK1 at K377, K604, K634" ;   Reactome:R-HSA-9796387 "STUB1 ubiquitinates RIPK1 at K571, K604, K627" ;   Reactome:R-HSA-9796626 "MIB2 ubiquitinates CFLAR" ;   Reactome:R-HSA-9815507 "MIB2 ubiquitinates CYLD at K338, K530" ;   Reactome:R-HSA-9817362 "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex" ;   Reactome:R-HSA-9833155 "Ubiquitination of STAT2" ;   Reactome:R-HSA-9833973 "ISGylation of PKR" ;   Reactome:R-HSA-9861563 "CTLH E3 ligase ubiquitinates LDHA" ;   Reactome:R-HSA-9861640 "CTLH E3 ligase ubiquitinates PKM-1" ;   reactome:R-HSA-1169394 "ISGylation of IRF3" ;   reactome:R-HSA-1169395 "ISGylation of viral protein NS1" ;   reactome:R-HSA-1169397 "Activation of ISG15 by UBA7 E1 ligase" ;   reactome:R-HSA-1169398 "ISGylation of host protein filamin B" ;   reactome:R-HSA-1169402 "ISGylation of E2 conjugating enzymes" ;   reactome:R-HSA-1169405 "ISGylation of protein phosphatase 1 beta (PP2CB)" ;   reactome:R-HSA-1169406 "ISGylation of host proteins" ;   reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha" ;   reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha" ;   reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH" ;   reactome:R-HSA-1358789 "Self-ubiquitination of RNF41" ;   reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3" ;   reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3" ;   reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)" ;   reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex" ;   reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2" ;   reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling" ;   reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1" ;   reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" ;   reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" ;   reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP" ;   reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" ;   reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" ;   reactome:R-HSA-179417 "Multiubiquitination of Nek2A" ;   reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G" ;   reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex" ;   reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85" ;   reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)" ;   reactome:R-HSA-183051 "CBL ubiquitinates Sprouty" ;   reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix" ;   reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty" ;   reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7" ;   reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21" ;   reactome:R-HSA-1912357 "ITCH ubiquitinates DTX" ;   reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand" ;   reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2" ;   reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2" ;   reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer" ;   reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1" ;   reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination" ;   reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling" ;   reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6" ;   reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6" ;   reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF" ;   reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex" ;   reactome:R-HSA-211734 "Ubiquitination of PAK-2p34" ;   reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7" ;   reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2" ;   reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3" ;   reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2" ;   reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7" ;   reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3" ;   reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3" ;   reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )" ;   reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels" ;   reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6" ;   reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants" ;   reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants" ;   reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants" ;   reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA" ;   reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56" ;   reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21" ;   reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1" ;   reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2" ;   reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1" ;   reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2" ;   reactome:R-HSA-400267 "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins" ;   reactome:R-HSA-4332236 "CBL neddylates TGFBR2" ;   reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated" ;   reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation" ;   reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1" ;   reactome:R-HSA-5205682 "Parkin promotes the ubiquitination of mitochondrial substrates" ;   reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1" ;   reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments" ;   reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated" ;   reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP" ;   reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex" ;   reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates" ;   reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1" ;   reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1" ;   reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2" ;   reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3" ;   reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA" ;   reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH" ;   reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA" ;   reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP" ;   reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP" ;   reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3" ;   reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK" ;   reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated" ;   reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2" ;   reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2" ;   reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains" ;   reactome:R-HSA-69598 "Ubiquitination of phosphorylated Cdc25A" ;   reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO" ;   reactome:R-HSA-75824 "Ubiquitination of Cyclin D1" ;   reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4" ;   reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3" ;   reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha" ;   reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3" ;   reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex" ;   reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex" ;   reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated" ;   reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2" ;   reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains" ;   reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation" ;   reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane" ;   reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2" ;   reactome:R-HSA-983153 "E1 mediated ubiquitin activation" ;   reactome:R-HSA-983156 "Polyubiquitination of substrate"
Definition Sources: GOC:BioGRID, GOC:jh2, PMID:9635407

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