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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased CD4-positive, alpha-beta T cell number
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Accession:MP:0008075 term browser browse the term
Definition:reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
Comment:Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625). Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624). T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
Synonyms:exact_synonym: decreased CD4+ T cell number;   decreased CD4-positive T cell number;   reduced CD4+ T cell number

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Path 1
Term Annotations click to browse term
  mammalian phenotype 0
    immune system phenotype 0
      abnormal immune system morphology 0
        abnormal immune system cell morphology 0
          abnormal leukocyte morphology 0
            abnormal leukocyte cell number 0
              abnormal lymphocyte cell number 0
                abnormal T cell number 0
                  abnormal alpha-beta T cell number 0
                    abnormal CD4-positive, alpha-beta T cell number 0
                      decreased CD4-positive, alpha-beta T cell number 0
                        absent CD4-positive, alpha-beta T cells 0
                        decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 0
                        decreased CD4-positive, alpha-beta memory T cell number + 0
                        decreased KLRG1+ CD4 alpha-beta T cell number 0
                        decreased T follicular helper cell number 0
                        decreased T helper 1 cell number 0
                        decreased T-helper 17 cell number 0
                        decreased T-helper 2 cell number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 0
    immune system phenotype 0
      abnormal immune system morphology 0
        abnormal immune system cell morphology 0
          abnormal leukocyte morphology 0
            abnormal mononuclear cell morphology 0
              abnormal lymphocyte morphology 0
                abnormal T cell morphology 0
                  abnormal effector T cell morphology 0
                    abnormal CD4-positive, alpha beta T cell morphology 0
                      abnormal CD4-positive, alpha-beta T cell number 0
                        decreased CD4-positive, alpha-beta T cell number 0
                          absent CD4-positive, alpha-beta T cells 0
                          decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 0
                          decreased CD4-positive, alpha-beta memory T cell number + 0
                          decreased KLRG1+ CD4 alpha-beta T cell number 0
                          decreased T follicular helper cell number 0
                          decreased T helper 1 cell number 0
                          decreased T-helper 17 cell number 0
                          decreased T-helper 2 cell number 0
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