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ONTOLOGY REPORT - ANNOTATIONS

Term:actin nucleation
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Accession:GO:0045010 term browser browse the term
Definition:The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
Synonyms:exact_synonym: actin filament nucleation


show annotations for term's descendants           Sort by:
actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Diaph1 diaphanous-related formin 1 acts_upstream_of_or_within ISO (PMID:21278336) RGD PMID:21278336 NCBI chr18:29,669,659...29,769,070
Ensembl chr18:29,669,659...29,769,172 		JBrowse link
G Diaph3 diaphanous-related formin 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:21278336)		 Ensembl
RGD		 PMID:21278336 GO_REF:0000107 NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975 		JBrowse link
G Fmn1 formin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220 		JBrowse link
G Fmn2 formin 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:86,454,256...86,771,437
Ensembl chr13:86,453,926...86,771,411 		JBrowse link
G Inf2 inverted formin 2 acts_upstream_of_or_within ISO (PMID:21278336) RGD PMID:21278336 NCBI chr 6:131,649,162...131,675,944
Ensembl chr 6:131,649,211...131,675,941 		JBrowse link
G Lmod1 leiomodin 1 involved_in ISO
IEA
ISS		 (PMID:26370058)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26370058 GO_REF:0000024 GO_REF:0000107 NCBI chr13:46,754,048...46,796,186
Ensembl chr13:46,754,033...46,794,900 		JBrowse link
G Lmod2 leiomodin 2 involved_in ISO
IEA
ISS		 (PMID:20685966), (PMID:25250574), (PMID:26370058)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20685966 PMID:25250574 PMID:26370058 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120 		JBrowse link
G Lmod3 leiomodin 3 involved_in ISO (PMID:25250574) RGD PMID:25250574 NCBI chr 4:129,843,964...129,858,684
Ensembl chr 4:129,843,970...129,858,244 		JBrowse link
G Spire1 spire-type actin nucleation factor 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:61,041,914...61,171,670
Ensembl chr18:61,041,290...61,171,899 		JBrowse link
G Spire2 spire-type actin nucleation factor 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:51,373,368...51,411,920
Ensembl chr19:51,373,228...51,411,920 		JBrowse link
'de novo' actin filament nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jmy junction mediating and regulatory protein, p53 cofactor involved_in ISO
IBA		 (MGI:4418600|PMID:19287377)
GO_REF:0000033		 RGD
GO_Central		 PMID:19287377 GO_REF:0000033 MGI:4418600 NCBI chr 2:24,662,104...24,730,955
Ensembl chr 2:24,668,854...24,731,006 		JBrowse link
Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07072283.2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr12:21,735,135...21,735,594 JBrowse link
G Actr2 actin related protein 2 involved_in ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:11741539), (PMID:17220302), (PMID:29925947)		 UniProt
Ensembl
GO_Central
RGD		 PMID:11741539 PMID:17220302 PMID:29925947 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524 		JBrowse link
G Actr3 actin related protein 3 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:11741539), (PMID:17220302)		 UniProt
GO_Central
RGD		 PMID:11741539 PMID:17220302 GO_REF:0000024 GO_REF:0000033 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Arpc1a actin related protein 2/3 complex, subunit 1A involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033
GO_REF:0000104		 InterPro
GO_Central
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr12:9,502,496...9,525,304
Ensembl chr12:9,502,501...9,525,330 		JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B involved_in ISO
IEA
IBA		 (PMID:11741539)
GO_REF:0000002
GO_REF:0000033		 RGD
InterPro
GO_Central		 PMID:11741539 GO_REF:0000002 GO_REF:0000033 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747 		JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 involved_in ISO
IBA
IEA		 (PMID:11741539)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002		 RGD
GO_Central
Ensembl
InterPro		 PMID:11741539 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471 		JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 involved_in ISO
IBA		 (PMID:11741539)
GO_REF:0000033		 RGD
GO_Central		 PMID:11741539 GO_REF:0000033 NCBI chr12:34,172,780...34,186,651
Ensembl chr12:34,172,780...34,186,651 		JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 involved_in ISO
IBA		 (PMID:11741539)
GO_REF:0000033		 RGD
GO_Central		 PMID:11741539 GO_REF:0000033 NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785 		JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 involved_in ISO
IBA
IEA		 (PMID:11741539)
GO_REF:0000033
GO_REF:0000002		 RGD
GO_Central
InterPro		 PMID:11741539 GO_REF:0000002 GO_REF:0000033 NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410 		JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
Ensembl chr 9:22,759,876...22,767,538 		JBrowse link
G Arpc5l-ps1 actin related protein 2/3 complex, subunit 5-like, pseudogene 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:45,263,352...45,264,349
Ensembl chr 9:45,262,374...45,264,366
Ensembl chr 9:45,262,374...45,264,366 		JBrowse link
G ENSRNOG00000065065 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr17:66,837,053...66,837,668 JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 involved_in ISO (PMID:12515716) RGD PMID:12515716 NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279 		JBrowse link
G Jmy junction mediating and regulatory protein, p53 cofactor involved_in ISO
IBA		 (MGI:4418600|PMID:19287377)
GO_REF:0000033		 RGD
GO_Central		 PMID:19287377 GO_REF:0000033 MGI:4418600 NCBI chr 2:24,662,104...24,730,955
Ensembl chr 2:24,668,854...24,731,006 		JBrowse link
G Magel2 MAGE family member L2 involved_in ISO (PMID:23452853) RGD PMID:23452853 NCBI chr 1:115,880,142...115,884,684
Ensembl chr 1:115,880,474...115,884,250 		JBrowse link
G Trim27 tripartite motif-containing 27 involved_in ISO (PMID:23452853) RGD PMID:23452853 NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643 		JBrowse link
G Washc1 WASH complex subunit 1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:23452853)
GO_REF:0000033
(PMID:18159949), (PMID:23452853)
GO_REF:0000002
(MGI:4415646|PMID:19922875)		 UniProt
RGD
GO_Central
InterPro		 PMID:18159949 PMID:19922875 PMID:23452853 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 MGI:4415646 NCBI chr 9:105,722,779...105,830,836
Ensembl chr 9:105,722,899...105,733,009 		JBrowse link
G Washc1-ps2 WASH complex subunit 1, pseudogene 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:106,097,337...106,103,219
Ensembl chr 9:106,097,498...106,100,342
Ensembl chr 9:106,097,498...106,100,342 		JBrowse link
G Whamm WASP homolog associated with actin, golgi membranes and microtubules involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:135,526,363...135,557,091
Ensembl chr 1:135,526,386...135,554,759 		JBrowse link
G Wipf3 WAS/WASL interacting protein family, member 3 involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 4:83,550,075...83,629,929
Ensembl chr 4:83,550,468...83,629,386 		JBrowse link
negative regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpin actin-related protein 2/3 complex inhibitor involved_in ISO
IBA		 (PMID:24132237)
GO_REF:0000033		 RGD
GO_Central		 PMID:24132237 GO_REF:0000033 NCBI chr 1:133,864,288...133,873,124
Ensembl chr 1:133,864,265...133,873,124 		JBrowse link
G Coro1a coronin 1A involved_in ISO (PMID:17442961) RGD PMID:17442961 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534 		JBrowse link
negative regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1b coronin 1B involved_in IEA
ISO		 GO_REF:0000107
(PMID:17350576), (PMID:18775315)		 Ensembl
RGD		 PMID:17350576 PMID:18775315 GO_REF:0000107 NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416 		JBrowse link
G Ctnna2 catenin alpha 2 involved_in ISO (PMID:30013181) RGD PMID:30013181 NCBI chr 4:109,294,249...110,443,409
Ensembl chr 4:109,293,978...110,443,522 		JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 involved_in ISO (PMID:32128961) RGD PMID:32128961 NCBI chr 2:234,947,910...235,006,173
Ensembl chr 2:234,929,677...235,006,173 		JBrowse link
G Gmfb glia maturation factor, beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331 		JBrowse link
G Gmfg glia maturation factor, gamma involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
(PMID:23727094)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:23727094 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:83,728,797...83,739,189
Ensembl chr 1:83,728,776...83,739,183 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (MGI:5805366|PMID:17318189) RGD PMID:17318189 MGI:5805366 NCBI chr12:32,590,164...32,618,841
Ensembl chr12:32,590,165...32,618,734 		JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IDA PMID:18297063 UniProt PMID:18297063 RGD:8554748 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848 		JBrowse link
positive regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmn1 formin 1 acts_upstream_of_or_within ISO (PMID:14647292) RGD PMID:14647292 NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220 		JBrowse link
G Gsn gelsolin involved_in ISO
IEA		 (PMID:19666531)
GO_REF:0000107		 RGD
Ensembl		 PMID:19666531 GO_REF:0000107 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Magel2 MAGE family member L2 acts_upstream_of_or_within ISO MGI:1916017 (PMID:23452853) RGD PMID:23452853 NCBI chr 1:115,880,142...115,884,684
Ensembl chr 1:115,880,474...115,884,250 		JBrowse link
G Scin scinderin involved_in ISO (PMID:19666531) RGD PMID:19666531 NCBI chr 6:57,109,500...57,188,123
Ensembl chr 6:57,109,403...57,188,242 		JBrowse link
G Trim27 tripartite motif-containing 27 acts_upstream_of_or_within ISO MGI:1916017 (PMID:23452853) RGD PMID:23452853 NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643 		JBrowse link
G Whamm WASP homolog associated with actin, golgi membranes and microtubules involved_in ISO (PMID:18614018) RGD PMID:18614018 NCBI chr 1:135,526,363...135,557,091
Ensembl chr 1:135,526,386...135,554,759 		JBrowse link
positive regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:61,827,139...61,905,699 		JBrowse link
G Brk1 BRICK1 subunit of SCAR/WAVE actin nucleating complex involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 4:146,750,821...146,766,050
Ensembl chr 4:146,750,821...146,768,856 		JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 1:106,710,924...106,799,393
Ensembl chr 1:106,711,016...106,799,386 		JBrowse link
G Fchsd2 FCH and double SH3 domains 2 involved_in ISO (PMID:29887380) RGD PMID:29887380 NCBI chr 1:155,444,471...155,685,350
Ensembl chr 1:155,444,460...155,685,539 		JBrowse link
G Nckap1 NCK-associated protein 1 involved_in ISO
IEA		 (PMID:21107423)
GO_REF:0000107		 RGD
Ensembl		 PMID:21107423 GO_REF:0000107 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217 		JBrowse link
G Wasf1 WASP family member 1 involved_in ISO
IEA
IBA		 (PMID:21107423)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:21107423 GO_REF:0000033 GO_REF:0000107 NCBI chr20:44,325,815...44,372,999
Ensembl chr20:44,325,795...44,372,996 		JBrowse link
G Wasf2 WASP family member 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:145,336,817...145,402,041
Ensembl chr 5:145,336,842...145,399,242 		JBrowse link
G Wasf3 WASP family member 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:8,563,805...8,660,799
Ensembl chr12:8,562,062...8,660,751 		JBrowse link
G Wasfl WASP family member 1 like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:73,040,984...73,043,716
Ensembl chr  X:73,040,902...73,043,716 		JBrowse link
regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vil1 villin 1 involved_in ISO (PMID:16921170), (PMID:17182858), (PMID:19808673) RGD PMID:16921170 PMID:17182858 PMID:19808673 NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858 		JBrowse link
G Washc5 WASH complex subunit 5 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3573938|MGI:5910638 (PMID:27390154)		 GO_Central
RGD		 PMID:27390154 GO_REF:0000033 NCBI chr 7:90,884,192...90,936,096
Ensembl chr 7:90,884,197...90,936,103 		JBrowse link
regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1ar adaptor-related protein complex 1 associated regulatory protein acts_upstream_of_or_within ISO MGI:1923959 (PMID:22689987) RGD PMID:22689987 NCBI chr 2:216,276,631...216,309,020
Ensembl chr 2:216,276,631...216,309,013 		JBrowse link
G Arf1 ADP-ribosylation factor 1 involved_in IDA PMID:23889934 UniProt PMID:23889934 RGD:8553918 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142 		JBrowse link
G Arfip2 ADP-ribosylation factor interacting protein 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:159,974,255...159,980,398
Ensembl chr 1:159,974,201...159,980,336 		JBrowse link
G Carmil1 capping protein regulator and myosin 1 linker 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965 		JBrowse link
G Carmil3 capping protein regulator and myosin 1 linker 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:28,978,440...28,995,865
Ensembl chr15:28,979,007...28,996,225 		JBrowse link
G Coro1b coronin 1B involved_in IC PMID:22619279 UniProt PMID:22619279 RGD:10047170 NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416 		JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848 		JBrowse link
G Rnh1 ribonuclease/angiogenin inhibitor 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:196,269,293...196,281,763
Ensembl chr 1:196,269,293...196,281,910 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    cellular process 18196
      actin filament-based process 844
        actin cytoskeleton organization 753
          actin filament organization 491
            actin nucleation 60
              'de novo' actin filament nucleation 1
              Arp2/3 complex-mediated actin nucleation + 44
              negative regulation of actin nucleation + 9
              positive regulation of actin nucleation + 15
              regulation of actin nucleation + 34
Path 2
Term Annotations click to browse term
  biological_process 19692
    cellular process 18196
      cellular component organization or biogenesis 6956
        cellular component organization 6692
          organelle organization 3681
            cytoskeleton organization 1530
              actin cytoskeleton organization 753
                actin filament organization 491
                  actin nucleation 60
                    'de novo' actin filament nucleation 1
                    Arp2/3 complex-mediated actin nucleation + 44
                    negative regulation of actin nucleation + 9
                    positive regulation of actin nucleation + 15
                    regulation of actin nucleation + 34
paths to the root