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ONTOLOGY REPORT - ANNOTATIONS

Term:radial spoke
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Accession:GO:0001534 term browser browse the term
Definition:Protein complex that links the outer microtubule doublet of a 9+2 type ciliary or flagellar axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.
Comment:Radial spokes are involved in some types of beating motions of the cilium. The radial spoke is usually a T-shaped structure comprised of a short base that attaches to the A-microtubule of an axonemal outer microtubule doublet (MTD) of a cilium, an elongated stalk, a neck complex, and an orthogonal head structure that extends perpendicularly towards the inner sheath and the central pair (CP) microtubules. Groups of radial spokes (RSs) repeat along the MTD with regular spacing. In most organisms, each group of radial spokes is comprised of a triplet of spokes: RS1, RS2, and RS3. In some organisms (e.g. Chlamydomonas and Sarcophaga bullata), each group contains a doublet of radial spokes: RS1 and RS2, while RS3 is represented only as a stump (referred to as RS3S) attached to the A-microtubule but lacking the rest of the stalk structure and entirely lacking the head structure. {xref="PMID:9450971", xref="GOC:krc", xref="PMID:34871179", xref="PMID:25694453"}
Synonyms:xref: Wikipedia:Radial_spoke


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radial spoke term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfap206 cilia and flagella associated protein 206 part_of ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:49,254,399...49,299,145
Ensembl chr 5:49,254,408...49,299,090 		JBrowse link
G Dnajb13 DnaJ heat shock protein family (Hsp40) member B13 part_of ISO (MGI:7407981|PMID:36417862) RGD PMID:36417862 MGI:7407981 NCBI chr 1:154,848,586...154,863,042
Ensembl chr 1:154,848,594...154,862,963 		JBrowse link
G Dydc1 DPY30 domain containing 1 part_of ISO (MGI:7407981|PMID:36417862) RGD PMID:36417862 MGI:7407981 NCBI chr16:16,940,946...16,961,462
Ensembl chr16:16,939,227...16,961,460 		JBrowse link
G Iqub IQ motif and ubiquitin domain containing part_of ISS
ISO		 GO_REF:0000024
(MGI:7407981|PMID:36417862)		 UniProt
RGD		 PMID:36417862 GO_REF:0000024 MGI:7407981 NCBI chr 4:52,931,768...52,993,795
Ensembl chr 4:52,931,767...52,993,834 		JBrowse link
G Nme5 NME/NM23 family member 5 part_of ISO (MGI:7407981|PMID:36417862) RGD PMID:36417862 MGI:7407981 NCBI chr18:26,163,558...26,180,742
Ensembl chr18:26,163,555...26,180,794 		JBrowse link
G Ropn1l rhophilin associated tail protein 1-like part_of ISO (MGI:7407981|PMID:36417862) RGD PMID:36417862 MGI:7407981 NCBI chr 2:82,442,645...82,453,332
Ensembl chr 2:82,441,891...82,453,485 		JBrowse link
G Rsph1 radial spoke head component 1 part_of ISO (MGI:7407981|PMID:36417862) RGD PMID:36417862 MGI:7407981 NCBI chr20:9,341,910...9,360,640
Ensembl chr20:9,341,913...9,360,640 		JBrowse link
G Rsph14 radial spoke head 14 homolog part_of ISO (MGI:7407981|PMID:36417862) RGD PMID:36417862 MGI:7407981 NCBI chr20:13,627,495...13,703,447
Ensembl chr20:13,629,000...13,703,449 		JBrowse link
G Rsph6a radial spoke head 6 homolog A part_of ISO (MGI:7407981|PMID:36417862) RGD PMID:36417862 MGI:7407981 NCBI chr 1:78,700,801...78,720,444
Ensembl chr 1:78,700,814...78,720,431 		JBrowse link
G Rsph9 radial spoke head component 9 part_of ISO (MGI:7407981|PMID:36417862) RGD PMID:36417862 MGI:7407981 NCBI chr 9:14,840,115...14,852,950
Ensembl chr 9:14,840,115...14,860,062 		JBrowse link
radial spoke head term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rsph1 radial spoke head component 1 part_of ISO (MGI:7447185|PMID:34871179) RGD PMID:34871179 MGI:7447185 NCBI chr20:9,341,910...9,360,640
Ensembl chr20:9,341,913...9,360,640 		JBrowse link
G Rsph4a radial spoke head component 4A part_of ISO MGI:5882201 (MGI:7447185|PMID:34871179), (PMID:26506310) RGD PMID:26506310 PMID:34871179 MGI:7447185 NCBI chr20:30,764,409...30,780,574
Ensembl chr20:30,764,409...30,780,574 		JBrowse link
G Rsph6a radial spoke head 6 homolog A part_of ISO UniProtKB:E9PYQ0|UniProtKB:Q8BYM7|UniProtKB:Q8VIG3|UniProtKB:Q9D9V4 (MGI:7447185|PMID:34871179), (PMID:30185526) RGD PMID:30185526 PMID:34871179 MGI:7447185 NCBI chr 1:78,700,801...78,720,444
Ensembl chr 1:78,700,814...78,720,431 		JBrowse link
G Rsph9 radial spoke head component 9 part_of ISO (MGI:7447185|PMID:34871179) RGD PMID:34871179 MGI:7447185 NCBI chr 9:14,840,115...14,852,950
Ensembl chr 9:14,840,115...14,860,062 		JBrowse link
radial spoke head 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rsph1 radial spoke head component 1 part_of ISO (PMID:34871179) RGD PMID:34871179 NCBI chr20:9,341,910...9,360,640
Ensembl chr20:9,341,913...9,360,640 		JBrowse link
G Rsph4a radial spoke head component 4A part_of ISO (PMID:32203505), (PMID:34871179) RGD PMID:32203505 PMID:34871179 NCBI chr20:30,764,409...30,780,574
Ensembl chr20:30,764,409...30,780,574 		JBrowse link
G Rsph9 radial spoke head component 9 part_of ISO (PMID:34871179) RGD PMID:34871179 NCBI chr 9:14,840,115...14,852,950
Ensembl chr 9:14,840,115...14,860,062 		JBrowse link
radial spoke head 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rsph4a radial spoke head component 4A part_of ISO (PMID:32203505) RGD PMID:32203505 NCBI chr20:30,764,409...30,780,574
Ensembl chr20:30,764,409...30,780,574 		JBrowse link
radial spoke head 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rsph1 radial spoke head component 1 part_of ISO (PMID:34871179) RGD PMID:34871179 NCBI chr20:9,341,910...9,360,640
Ensembl chr20:9,341,913...9,360,640 		JBrowse link
G Rsph4a radial spoke head component 4A part_of ISO (PMID:32203505), (PMID:34871179) RGD PMID:32203505 PMID:34871179 NCBI chr20:30,764,409...30,780,574
Ensembl chr20:30,764,409...30,780,574 		JBrowse link
G Rsph9 radial spoke head component 9 part_of ISO (PMID:34871179) RGD PMID:34871179 NCBI chr 9:14,840,115...14,852,950
Ensembl chr 9:14,840,115...14,860,062 		JBrowse link
radial spoke stalk term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfap61 cilia and flagella associated protein 61 part_of ISO PR:B2RY50|PR:Q3UFY4|PR:Q9EQ00|PR:Q9ESG2 (PMID:34792097) RGD PMID:34792097 NCBI chr 3:133,354,400...133,633,310
Ensembl chr 3:133,354,197...133,633,320 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21392
    protein-containing complex 6987
      radial spoke 12
        radial spoke 1 + 3
        radial spoke 2 + 1
        radial spoke 3 + 3
        radial spoke base + 0
        radial spoke head + 4
        radial spoke neck 0
        radial spoke stalk 1
Path 2
Term Annotations click to browse term
  cellular_component 21392
    cellular anatomical entity 21234
      intracellular anatomical structure 15673
        cytoplasm 12359
          cytoplasmic region 355
            plasma membrane bounded cell projection cytoplasm 312
              ciliary plasm 199
                axoneme 198
                  radial spoke 12
                    radial spoke 1 + 3
                    radial spoke 2 + 1
                    radial spoke 3 + 3
                    radial spoke base + 0
                    radial spoke head + 4
                    radial spoke neck 0
                    radial spoke stalk 1
paths to the root