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ONTOLOGY REPORT - ANNOTATIONS

Term:branched-chain alpha-ketoacid dehydrogenase complex
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Accession:GO:0160157 term browser browse the term
Definition:A multi-enzyme complex that catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: branched-chain alpha-ketoacid dehydrogenase (E1, a heterotetramer of two alpha and two beta subunits), dihydrolipoyl transacylase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.
Comment:The catalytic activities of the individual components of this complex are represented by the molecular function terms '3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity ; GO:0003863' (E1), 'dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity ; GO:0043754' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'branched-chain alpha-keto acid dehydrogenase activity (GO:0047101)'.
Synonyms:exact_synonym: BCKD complex;   BKDH complex
 xref: Wikipedia:Branched-chain_alpha-keto_acid_dehydrogenase_complex


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branched-chain alpha-ketoacid dehydrogenase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha part_of ISO
ISS		 (PMID:10745006)
GO_REF:0000024		 RGD
UniProt		 PMID:10745006 GO_REF:0000024 NCBI chr 1:81,138,946...81,167,765
Ensembl chr 1:81,138,947...81,167,862 		JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta part_of ISO
ISS		 (PMID:10745006)
GO_REF:0000024		 RGD
UniProt		 PMID:10745006 GO_REF:0000024 NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812 		JBrowse link
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  cellular_component 20624
    protein-containing complex 6599
      catalytic complex 1823
        oxidoreductase complex 188
          alpha-ketoacid dehydrogenase complex 17
            branched-chain alpha-ketoacid dehydrogenase complex 2
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