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ONTOLOGY REPORT - ANNOTATIONS

Term:folic acid:proton symporter activity
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Accession:GO:0140211 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid.
Synonyms:xref: TC:2.A.1.50.1


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folic acid:proton symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc46a1 solute carrier family 46 member 1 enables ISO (PMID:19389703), (PMID:34040256)
(MGI:3762977|PMID:17962486)		 RGD PMID:17962486 PMID:19389703 PMID:34040256 MGI:3762977 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20487
    transporter activity 1237
      transmembrane transporter activity 1143
        amide transmembrane transporter activity 36
          folic acid transmembrane transporter activity 4
            folic acid:proton symporter activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20487
    transporter activity 1237
      transmembrane transporter activity 1143
        active transmembrane transporter activity 444
          secondary active transmembrane transporter activity 289
            symporter activity 139
              solute:monoatomic cation symporter activity 113
                solute:proton symporter activity 19
                  folic acid:proton symporter activity 1
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