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ONTOLOGY REPORT - ANNOTATIONS

Term:ESC/E(Z) complex
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Accession:GO:0035098 term browser browse the term
Definition:A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.
Synonyms:exact_synonym: Extra Sex Combs/Enhancer of Zeste complex;   PRC2 complex

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ESC/E(Z) complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aebp2 AE binding protein 2 part_of ISO (PMID:20075857)
(MGI:4431292|PMID:20064375), (MGI:4436818|PMID:20064376), (PMID:31451685)		 UniProt PMID:20064375 PMID:20064376 PMID:20075857 PMID:31451685 MGI:4431292 MGI:4436818 NCBI chrNW_004955413:15,514,247...15,561,233
Ensembl chrNW_004955413:15,495,073...15,561,227 		JBrowse link
G Dnmt3l DNA methyltransferase 3 like part_of ISO (MGI:5553039|PMID:24074865) UniProt PMID:24074865 MGI:5553039 NCBI chrNW_004955407:41,177,582...41,186,965
Ensembl chrNW_004955407:41,177,582...41,186,965 		JBrowse link
G Eed embryonic ectoderm development part_of ISO (PMID:15385962), (PMID:20075857), (PMID:23104054), (PMID:23273982)
(MGI:4429983|PMID:20144788), (MGI:4431292|PMID:20064375), (MGI:4436818|PMID:20064376), (MGI:5318799|PMID:22438827), (PMID:31451685)		 UniProt PMID:15385962 PMID:20064375 PMID:20064376 PMID:20075857 PMID:20144788 More... MGI:4429983 MGI:4431292 MGI:4436818 MGI:5318799 NCBI chrNW_004955414:6,659,144...6,685,530
Ensembl chrNW_004955414:6,659,055...6,685,530 		JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit part_of ISO (PMID:20075857)
(MGI:3820717|PMID:19026781), (MGI:4429983|PMID:20144788), (MGI:4436818|PMID:20064376), (MGI:5318799|PMID:22438827), (PMID:31451685)		 UniProt PMID:19026781 PMID:20064376 PMID:20075857 PMID:20144788 PMID:22438827 More... MGI:3820717 MGI:4429983 MGI:4436818 MGI:5318799 NCBI chrNW_004955451:16,548,898...16,563,449
Ensembl chrNW_004955451:16,548,858...16,564,310 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit part_of ISO (PMID:15385962), (PMID:20075857), (PMID:23104054), (PMID:23273982), (PMID:24474760)
(MGI:3820717|PMID:19026781), (MGI:4429983|PMID:20144788), (MGI:4431292|PMID:20064375), (MGI:4436818|PMID:20064376), (MGI:5318799|PMID:22438827), (MGI:5487475|PMID:23160351), (PMID:31451685)		 MGI
UniProt		 PMID:15385962 PMID:19026781 PMID:20064375 PMID:20064376 PMID:20075857 More... MGI:3820717 MGI:4429983 MGI:4431292 MGI:4436818 MGI:5318799 MGI:5487475 NCBI chrNW_004955491:4,215,353...4,292,229
Ensembl chrNW_004955491:4,215,298...4,292,235 		JBrowse link
G Hdac2 histone deacetylase 2 part_of ISO (PMID:20075857) UniProt PMID:20075857 NCBI chrNW_004955526:2,739,099...2,759,640
Ensembl chrNW_004955526:2,728,377...2,759,707 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 part_of ISO (MGI:4431292|PMID:20064375), (MGI:4436818|PMID:20064376), (PMID:31451685) MGI PMID:20064375 PMID:20064376 PMID:31451685 MGI:4431292 MGI:4436818 NCBI chrNW_004955590:383,810...512,854
Ensembl chrNW_004955590:384,817...626,684 		JBrowse link
G Mtf2 metal response element binding transcription factor 2 part_of ISO (MGI:4429983|PMID:20144788) UniProt PMID:20144788 MGI:4429983 NCBI chrNW_004955423:1,469,498...1,534,082
Ensembl chrNW_004955423:1,469,498...1,534,082 		JBrowse link
G Phf1 PHD finger protein 1 located_in
part_of		 ISO (PMID:23273982)
(PMID:31451685)		 UniProt
MGI		 PMID:23273982 PMID:31451685 NCBI chrNW_004955437:1,943,049...1,947,027
Ensembl chrNW_004955437:1,943,065...1,946,705 		JBrowse link
G Phf19 PHD finger protein 19 part_of
located_in		 ISO (MGI:5318799|PMID:22438827), (MGI:5487475|PMID:23160351)
(PMID:23104054)		 UniProt PMID:22438827 PMID:23104054 PMID:23160351 MGI:5318799 MGI:5487475 NCBI chrNW_004955419:7,160,249...7,179,323
Ensembl chrNW_004955419:7,160,249...7,179,318 		JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor part_of ISO (PMID:20075857), (PMID:23104054), (PMID:23273982)
(MGI:4436818|PMID:20064376), (PMID:31451685)		 UniProt
MGI		 PMID:20064376 PMID:20075857 PMID:23104054 PMID:23273982 PMID:31451685 MGI:4436818 NCBI chrNW_004955452:10,955,399...10,975,036
Ensembl chrNW_004955452:10,955,399...10,975,036 		JBrowse link
G Rbbp7 RB binding protein 7, chromatin remodeling factor part_of ISO (PMID:20075857), (PMID:23104054), (PMID:23273982)
(PMID:31451685)		 UniProt
MGI		 PMID:20075857 PMID:23104054 PMID:23273982 PMID:31451685 NCBI chrNW_004955519:1,460,199...1,482,699 JBrowse link
G Sirt1 sirtuin 1 located_in ISO (PMID:15684044) UniProt PMID:15684044 NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663 		JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit part_of ISO (PMID:20075857), (PMID:23104054), (PMID:23273982)
(PMID:15385962)
(MGI:4429983|PMID:20144788), (MGI:4431292|PMID:20064375), (MGI:4436818|PMID:20064376), (MGI:5318799|PMID:22438827), (MGI:5487475|PMID:23160351), (PMID:31451685)		 UniProt
MGI		 PMID:15385962 PMID:20064375 PMID:20064376 PMID:20075857 PMID:20144788 More... MGI:4429983 MGI:4431292 MGI:4436818 MGI:5318799 MGI:5487475 NCBI chrNW_004955481:6,867,175...6,917,548
Ensembl chrNW_004955481:6,867,175...6,917,548 		JBrowse link
G Trim37 tripartite motif containing 37 located_in ISO (PMID:25470042) UniProt PMID:25470042 NCBI chrNW_004955451:3,839,757...4,014,178
Ensembl chrNW_004955451:3,878,416...3,989,208 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12560
    protein-containing complex 4414
      nuclear protein-containing complex 976
        PcG protein complex 44
          ESC/E(Z) complex 15
Path 2
Term Annotations click to browse term
  cellular_component 12560
    cellular anatomical entity 12401
      organelle 9810
        membrane-bounded organelle 8933
          intracellular membrane-bounded organelle 8484
            nucleus 5236
              nuclear lumen 3565
                nucleoplasm 3197
                  histone methyltransferase complex 62
                    ESC/E(Z) complex 15
paths to the root