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ONTOLOGY REPORT - ANNOTATIONS

Term:NMDA glutamate receptor activity
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Accession:GO:0004972 term browser browse the term
Definition:An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages.
Comment:The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product.
Synonyms:exact_synonym: N-methyl-D-aspartate selective glutamate receptor activity;   NMDA receptor
 xref: Wikipedia:NMDA_receptor

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NMDA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 enables
contributes_to		 ISO
IEA		 (PMID:7679115), (PMID:7685113) RGD
TreeGrafter
UniProtKB		 PMID:7679115 PMID:7685113 PMID:16477151 PMID:17050728 PMID:22098737 GO_REF:0000118 RGD:1642190 RGD:1642380 RGD:7241434 NCBI chr12:1,020,556...1,050,568
Ensembl chr12:1,019,263...1,050,231 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A contributes_to
enables		 ISO
IEA		 (PMID:1374164)
(PMID:7929101)		 RGD
MGI
TreeGrafter
Ensembl		 PMID:1374164 PMID:7929101 PMID:8428958 PMID:16477151 PMID:17050728 More... GO_REF:0000107 GO_REF:0000118 RGD:1642190 RGD:1642380 RGD:7241434 RGD:728651 NCBI chr 5:9,233,028...9,707,322
Ensembl chr 5:9,286,775...9,462,828 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:1350383 PMID:16477151 GO_REF:0000107 GO_REF:0000118 RGD:1642190 RGD:727540 NCBI chr11:13,444,155...13,873,034
Ensembl chr11:13,456,968...13,873,202 		JBrowse link
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C enables
contributes_to		 ISO
IEA		 (PMID:7929101) RGD
TreeGrafter
MGI		 PMID:7929101 PMID:8428958 GO_REF:0000118 RGD:728651 NCBI chr16:46,797,136...46,816,703
Ensembl chr16:46,803,535...46,816,292 		JBrowse link
G GRIN2D glutamate ionotropic receptor NMDA type subunit 2D enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:7512349 PMID:15107472 PMID:17050728 GO_REF:0000107 GO_REF:0000118 RGD:1642380 RGD:1642397 RGD:728580 NCBI chr 6:41,650,458...41,707,024
Ensembl chr 6:41,656,334...41,706,030 		JBrowse link
G GRIN3A glutamate ionotropic receptor NMDA type subunit 3A contributes_to
enables		 ISO
IEA		 PMID:17182766 UniProt
TreeGrafter
RGD		 PMID:16477151 PMID:17182766 GO_REF:0000118 RGD:1642190 RGD:8553928 NCBI chr12:37,700,311...37,865,390
Ensembl chr12:37,701,039...37,867,041 		JBrowse link
G GRIN3B glutamate ionotropic receptor NMDA type subunit 3B enables IEA TreeGrafter GO_REF:0000118 NCBI chr 6:756,257...766,175
Ensembl chr 6:756,618...766,048 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18050
    transporter activity 1200
      transmembrane transporter activity 1111
        amino acid transmembrane transporter activity 99
          glutamate-gated receptor activity 17
            NMDA glutamate receptor activity 7
Path 2
Term Annotations click to browse term
  molecular_function 18050
    transporter activity 1200
      transmembrane transporter activity 1111
        passive transmembrane transporter activity 521
          channel activity 521
            gated channel activity 334
              ligand-gated channel activity 195
                ligand-gated monoatomic ion channel activity 191
                  extracellular ligand-gated monoatomic ion channel activity 80
                    transmitter-gated monoatomic ion channel activity 69
                      glutamate-gated receptor activity 17
                        NMDA glutamate receptor activity 7
paths to the root