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ONTOLOGY REPORT - ANNOTATIONS

Term:diacylglycerol-dependent serine/threonine kinase activity
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Accession:GO:0004697 term browser browse the term
Definition:Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
Synonyms:exact_synonym: PKC activity;   diacylglycerol-activated phospholipid-dependent PKC activity;   diacylglycerol-activated phospholipid-dependent protein kinase C activity
 narrow_synonym: protein kinase Cepsilon activity
 related_synonym: ATP:protein phosphotransferase (diacylglycerol-dependent) activity;   PKC;   PKCalpha;   PKCbeta;   PKCdelta;   PKCepsilon;   PKCgamma;   Pkc1p;   STK24;   cPKC;   cPKCalpha;   cPKCbeta;   cPKCgamma;   nPKC;   nPKCdelta;   nPKCepsilon;   nPKCeta;   nPKCtheta
 alt_id: GO:0004701
 xref: EC:2.7.11.13;   Reactome:R-HSA-1433508 "PKC alpha interacts with and phosphorylates KIT";   Reactome:R-HSA-193703 "IKKbeta is activated";   Reactome:R-HSA-2730863 "Phosphorylation of CARMA1 by PKC-theta";   Reactome:R-HSA-374664 "Phosphorylation and activation of Ezrin";   Reactome:R-HSA-429698 "PRKD1,2,3 phosphorylates CERT1-2";   Reactome:R-HSA-450533 "PKCdelta phosphorylates HuR";   Reactome:R-HSA-450550 "PKCalpha phosphorylates HuR";   Reactome:R-HSA-5218823 "PKC phosphorylates sphingosine kinase 1";   Reactome:R-HSA-5229194 "Depolymerization of lamin filaments after PKC-mediated phosphorylation";   Reactome:R-HSA-5623667 "PDPK1 phosphorylates PKN1,2,3";   Reactome:R-HSA-5625784 "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters";   Reactome:R-HSA-5671749 "p-T774-PKN1 phosphorylates CDC25C";   Reactome:R-HSA-74615 "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP";   Reactome:R-HSA-8932284 "PKC phosphorylates NFE2L2";   Reactome:R-HSA-8934446 "Activated PKC phosphorylates SHC1";   Reactome:R-HSA-9010681 "PKC phosphorylates ROBO3.1";   Reactome:R-HSA-9021357 "PRKCI phosphorylates ELF3";   Reactome:R-HSA-909552 "Phosphorylation of STAT1 at Ser727";   Reactome:R-HSA-927889 "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)";   Reactome:R-HSA-9632858 "PRKCZ autophosphorylates downstream of estrogen stimulation";   Reactome:R-HSA-9796053 "PRKCI phosphorylates NFE2L2";   reactome:R-HSA-198314 "DAG stimulates protein kinase C-delta";   reactome:R-HSA-2179413 "Activated PKC-alpha activate MMP3";   reactome:R-HSA-5138432 "DVL2 is phosphorylated by PKC";   reactome:R-HSA-5218805 "PKC autophosphorylates";   reactome:R-HSA-751040 "PKC phosphorylates G alpha (z)";   reactome:R-HSA-9626817 "PKC phosphorylates NCF1"

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show annotations for term's descendants           Sort by:
diacylglycerol-dependent serine/threonine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkn1 protein kinase N1 enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624901:1,582,790...1,605,279 JBrowse link
G Pkn2 protein kinase N2 enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624742:8,740,102...8,865,483
Ensembl chrNW_004624742:8,742,473...8,865,281 		JBrowse link
G Pkn3 protein kinase N3 enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624760:6,276,714...6,286,861
Ensembl chrNW_004624760:6,277,005...6,285,744 		JBrowse link
G Prkca protein kinase C alpha enables ISO
IEA		 RGD
UniProt
InterPro		 PMID:9705215 PMID:15272003 PMID:20074623 GO_REF:0000002 GO_REF:0000003 RGD:1601478 RGD:5131655 RGD:5131880 NCBI chrNW_004624870:1,589,775...2,023,160
Ensembl chrNW_004624870:1,596,102...2,023,172 		JBrowse link
G Prkcb protein kinase C beta enables ISO
IEA		 RGD
InterPro
UniProt		 PMID:11507002 GO_REF:0000002 GO_REF:0000003 RGD:631236 NCBI chrNW_004624782:8,974,995...9,287,609
Ensembl chrNW_004624782:8,974,765...9,287,702 		JBrowse link
G Prkcd protein kinase C delta enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 NCBI chrNW_004624822:4,035,819...4,062,907
Ensembl chrNW_004624822:4,033,130...4,059,555 		JBrowse link
G Prkce protein kinase C epsilon enables ISO (PMID:18556656)
PMID:22619279		 BHF-UCL
UniProt		 PMID:18556656 PMID:22619279 RGD:10047170 NCBI chrNW_004624738:27,118,764...27,630,733
Ensembl chrNW_004624738:27,118,145...27,627,606 		JBrowse link
G Prkcg protein kinase C gamma enables ISO
IEA		 RGD
UniProt
InterPro		 PMID:11507002 GO_REF:0000002 GO_REF:0000003 RGD:631236 NCBI chrNW_004624832:2,548,286...2,566,365
Ensembl chrNW_004624832:2,547,535...2,566,402 		JBrowse link
G Prkch protein kinase C eta enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 NCBI chrNW_004624734:39,620,690...39,830,281
Ensembl chrNW_004624734:39,619,273...39,830,353 		JBrowse link
G Prkci protein kinase C iota enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624730:48,258,524...48,340,217 JBrowse link
G Prkcq protein kinase C theta enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 NCBI chrNW_004624775:1,419,596...1,543,805
Ensembl chrNW_004624775:1,419,509...1,502,064 		JBrowse link
G Prkcz protein kinase C zeta enables ISO
IEA		 RGD
UniProt		 PMID:20570724 GO_REF:0000003 RGD:5131661 NCBI chrNW_004624818:7,758,192...7,846,950
Ensembl chrNW_004624818:7,759,770...7,847,208 		JBrowse link
G Prkd1 protein kinase D1 enables ISO (PMID:12637538) CACAO PMID:12637538 NCBI chrNW_004624820:2,408,562...2,726,199
Ensembl chrNW_004624820:2,408,360...2,726,606 		JBrowse link
G Prkd2 protein kinase D2 enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624832:6,885,627...6,915,316
Ensembl chrNW_004624832:6,886,327...6,915,179 		JBrowse link
G Prkd3 protein kinase D3 enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624738:18,851,165...18,927,177
Ensembl chrNW_004624738:18,853,963...18,927,122 		JBrowse link
G Smg1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase enables ISO (PMID:11544179) Reactome PMID:11544179 NCBI chrNW_004624782:2,253,604...2,349,590
Ensembl chrNW_004624782:2,255,333...2,349,547 		JBrowse link
calcium,diacylglycerol-dependent serine/threonine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkca protein kinase C alpha enables ISO (PMID:10879655), (PMID:7741753)
(PMID:33934390)
(MGI:5882922|PMID:7828597)
(PMID:25313067)		 MGI
RGD
UniProt
CAFA		 PMID:7741753 PMID:7828597 PMID:9046017 PMID:10879655 PMID:18972403 More... MGI:5882922 RGD:5131882 RGD:731217 NCBI chrNW_004624870:1,589,775...2,023,160
Ensembl chrNW_004624870:1,596,102...2,023,172 		JBrowse link
G Prkcg protein kinase C gamma ISO RGD PMID:18972403 RGD:5131882 NCBI chrNW_004624832:2,548,286...2,566,365
Ensembl chrNW_004624832:2,547,535...2,566,402 		JBrowse link
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcd protein kinase C delta ISO RGD PMID:1915352 RGD:1642551 NCBI chrNW_004624822:4,035,819...4,062,907
Ensembl chrNW_004624822:4,033,130...4,059,555 		JBrowse link
G Prkce protein kinase C epsilon enables ISO (PMID:10879655) MGI PMID:10879655 NCBI chrNW_004624738:27,118,764...27,630,733
Ensembl chrNW_004624738:27,118,145...27,627,606 		JBrowse link
G Prkch protein kinase C eta ISO RGD PMID:1426252 RGD:729427 NCBI chrNW_004624734:39,620,690...39,830,281
Ensembl chrNW_004624734:39,619,273...39,830,353 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16258
    catalytic activity 5070
      catalytic activity, acting on a protein 2057
        protein kinase activity 535
          protein serine/threonine kinase activity 380
            diacylglycerol-dependent serine/threonine kinase activity 16
              calcium,diacylglycerol-dependent serine/threonine kinase activity 2
              diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3
Path 2
Term Annotations click to browse term
  molecular_function 16258
    catalytic activity 5070
      transferase activity 2174
        transferase activity, transferring phosphorus-containing groups 913
          kinase activity 780
            protein kinase activity 535
              protein serine/threonine kinase activity 380
                diacylglycerol-dependent serine/threonine kinase activity 16
                  calcium,diacylglycerol-dependent serine/threonine kinase activity 2
                  diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3
paths to the root