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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:appendicitis
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Accession:DOID:8337 term browser browse the term
Definition:A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever. (DO)
Synonyms:exact_synonym: Perforated Appendicitis;   acute appendicitis;   acute appendicitis with generalized peritonitis;   acute appendicitis with peritoneal abscess;   ruptured appendicitis
 primary_id: MESH:D001064
 alt_id: OMIM:107700
 xref: EFO:0007149;   ICD10CM:K37;   ICD9CM:540-543.99;   NCI:C35145
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
appendicitis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin ISO RGD PMID:21663567 RGD:5147751 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:16367942 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16367942 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Plau plasminogen activator, urokinase ISO protein:increased expression:appendix RGD PMID:19153874 RGD:6483822 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Ret ret proto-oncogene ISO ClinVar Annotator: match by term: Appendicitis ClinVar PMID:11230481 PMID:15320968 PMID:16384843 PMID:16849421 PMID:18058472 More... NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21126
    disease by infectious agent 2211
      Intraabdominal Infections 45
        appendicitis 5
Path 2
Term Annotations click to browse term
  disease 21126
    disease of anatomical entity 18213
      gastrointestinal system disease 7051
        intestinal disease 3074
          cecal disease 12
            appendicitis 5
paths to the root