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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Nervous System Lead Poisoning
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Accession:DOID:9007159 term browser browse the term
Definition:Injury to the nervous system secondary to exposure to lead compounds. Two distinct clinical patterns occur in children (LEAD POISONING, NERVOUS SYSTEM, CHILDHOOD) and adults (LEAD POISONING, NERVOUS SYSTEM, ADULT). In children, lead poisoning typically produces an encephalopathy. In adults, exposure to toxic levels of lead is associated with a peripheral neuropathy.
Synonyms:exact_synonym: Lead Neurotoxicity Syndrome;   Lead Neurotoxicity Syndromes;   Lead-Induced Nervous System Diseases;   Nervous System Plumbism;   Neurologic Lead Poisoning;   Neurologic Plumbism
 primary_id: MESH:D020263


show annotations for term's descendants           Sort by:
Nervous System Lead Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21439310 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Ep300 E1A binding protein p300 IEP mRNA:increased expression:hippocampus RGD PMID:24291742 RGD:9588309 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
Nervous System Lead Poisoning, Adult term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a1 solute carrier family 6 member 1 IEP protein:increased expression:brain, synaptosome RGD PMID:15149801 RGD:1643208 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    syndrome 10889
      toxic encephalopathy 237
        Heavy Metal Poisoning, Nervous System 86
          Nervous System Lead Poisoning 3
            Nervous System Lead Poisoning, Adult 1
            Nervous System Lead Poisoning, Childhood 0
Path 2
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      nervous system disease 14091
        toxic encephalopathy 237
          Heavy Metal Poisoning, Nervous System 86
            Nervous System Lead Poisoning 3
              Nervous System Lead Poisoning, Adult 1
              Nervous System Lead Poisoning, Childhood 0
paths to the root