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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hypothermia
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Accession:DOID:9002395 term browser browse the term
Definition:Lower than normal body temperature, especially in warm-blooded animals.
Synonyms:exact_synonym: Accidental Hypothermia;   Accidental Hypothermias;   Hypothermias
 primary_id: MESH:D007035

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Hypothermia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator ISO mRNA:increased expression:prostate gland ventral lobe (rat) RGD PMID:25996932 RGD:10402397 NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895 		JBrowse link
G BTK Bruton tyrosine kinase exacerbates ISO Associated with Endotoxemia; with Itk knockout RGD PMID:26581914 RGD:11533169 NCBI chr  X:89,690,569...89,727,420 JBrowse link
G CCL20 C-C motif chemokine ligand 20 ISO RGD PMID:16469832 RGD:2311385 NCBI chr10:113,815,099...113,836,562
Ensembl chr10:113,832,573...113,835,736 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:14982698 NCBI chr20:9,245,803...9,255,430
Ensembl chr20:9,247,231...9,253,795 		JBrowse link
G CIRBP cold inducible RNA binding protein severity ISO RGD PMID:31271215 RGD:329961299 NCBI chr 6:1,037,389...1,043,265
Ensembl chr 6:1,039,401...1,042,187 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9888857 PMID:27149200 PMID:27535976 PMID:31877572 NCBI chr13:12,626,259...12,653,253
Ensembl chr13:12,630,270...12,631,688 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:16469832 RGD:2311385 NCBI chr 7:24,526,657...24,529,193
Ensembl chr 7:24,526,680...24,529,130 		JBrowse link
G FASLG Fas ligand ISO associated with Brain Ischemia RGD PMID:18410517 RGD:2311437 NCBI chr25:56,488,572...56,496,469
Ensembl chr25:56,489,417...56,496,251 		JBrowse link
G GCG glucagon ISO CTD Direct Evidence: therapeutic CTD PMID:10464538 NCBI chr10:47,550,097...47,560,610 JBrowse link
G GNRH1 gonadotropin releasing hormone 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:6350720 NCBI chr 8:23,543,717...23,550,728
Ensembl chr 8:23,542,806...23,547,771 		JBrowse link
G HCRT hypocretin neuropeptide precursor ISO CTD Direct Evidence: marker/mechanism CTD PMID:26799708 NCBI chr16:64,083,199...64,085,393
Ensembl chr16:64,084,070...64,085,292 		JBrowse link
G HSF1 heat shock transcription factor 1 ISO mRNA:increased expression:prostate gland ventral lobe (rat) RGD PMID:25996932 RGD:10402397 NCBI chr 8:138,503,836...138,529,562
Ensembl chr 8:138,503,831...138,529,165 		JBrowse link
G IL12A interleukin 12A ISO CTD Direct Evidence: marker/mechanism CTD PMID:16369138 NCBI chr15:30,887,048...30,896,577
Ensembl chr15:30,887,897...30,894,550 		JBrowse link
G IL12B interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16369138 NCBI chr23:61,714,293...61,731,835 JBrowse link
G LHB luteinizing hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:6350720 NCBI chr 6:42,247,254...42,248,822 JBrowse link
G LOC103247057 acyl-CoA synthetase short chain family member 1 ISO RGD PMID:19187775 RGD:13831305
G MDM2 MDM2 proto-oncogene ISO associated with Reperfusion Injury; protein:increased expression:hippocampus (rat) RGD PMID:15777295 RGD:2317393 NCBI chr11:64,434,203...64,465,490
Ensembl chr11:64,434,261...64,469,890 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:30366073 NCBI chr28:8,334,172...8,349,828
Ensembl chr28:8,332,772...8,349,804 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:24675228 NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257 		JBrowse link
G OPRD1 opioid receptor delta 1 ISO mRNA:increased expression:hypothalamus RGD PMID:21377399 RGD:401901086 NCBI chr20:103,950,505...104,002,459 JBrowse link
G PPBP pro-platelet basic protein ISO protein:increased expression:plasma RGD PMID:31237986 RGD:401794437 NCBI chr 7:22,470,670...22,471,841
Ensembl chr 7:22,470,573...22,471,809 		JBrowse link
G PRKCD protein kinase C delta ISO CTD Direct Evidence: therapeutic CTD PMID:30366073 NCBI chr22:14,561,401...14,592,877
Ensembl chr22:14,565,282...14,592,873 		JBrowse link
G SELP selectin P ISO protein:increased expression: red pulp of spleen RGD PMID:31237986 RGD:401794437 NCBI chr25:59,420,910...59,465,140
Ensembl chr25:59,433,333...59,462,598 		JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11731100 NCBI chr 2:60,461,219...60,472,999 JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16369138 PMID:34942311
G TRH thyrotropin releasing hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:6350720 NCBI chr22:51,075,814...51,079,852
Ensembl chr22:51,076,157...51,078,236 		JBrowse link
G TSHB thyroid stimulating hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:6350720 NCBI chr20:18,660,683...18,665,226
Ensembl chr20:18,657,535...18,665,185 		JBrowse link
G TTR transthyretin ISO mRNA:decreased expression:frontal cortex RGD PMID:21377399 RGD:401901086 NCBI chr18:49,124,302...49,131,495
Ensembl chr18:49,124,121...49,131,399 		JBrowse link
G VWF von Willebrand factor ISO mRNA,protein:increased expression:spleen RGD PMID:31237986 RGD:401794437 NCBI chr11:5,994,499...6,176,949
Ensembl chr11:5,994,039...6,162,260 		JBrowse link
G ZFP91 ZFP91 zinc finger protein, atypical E3 ubiquitin ligase ISO CTD Direct Evidence: therapeutic CTD PMID:34942311 NCBI chr 1:14,733,279...14,776,333
Ensembl chr 1:14,735,662...14,776,167 		JBrowse link
Malignant Hypothermia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 ISO ClinVar Annotator: match by term: Malignant hypothermia ClinVar PMID:14732627 PMID:16163667 PMID:16732084 PMID:16917943 PMID:18253926 More... NCBI chr 6:33,080,443...33,234,478
Ensembl chr 6:33,080,758...33,213,788 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15274
    Pathological Conditions, Signs and Symptoms 11782
      Signs and Symptoms 9746
        Body Temperature Changes 103
          Hypothermia 31
            Malignant Hypothermia 1
            Recurrent Spontaneous Hypothermia with Hypoplasia of the Corpus Callosum 0
            Shapiro Syndrome 0
paths to the root