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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:appendicitis
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Accession:DOID:8337 term browser browse the term
Definition:A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever. (DO)
Synonyms:exact_synonym: Perforated Appendicitis;   acute appendicitis;   acute appendicitis with generalized peritonitis;   acute appendicitis with peritoneal abscess;   ruptured appendicitis
 primary_id: MESH:D001064
 alt_id: OMIM:107700
 xref: EFO:0007149;   ICD10CM:K37;   ICD9CM:540-543.99;   NCI:C35145
For additional species annotation, visit the Alliance of Genome Resources.

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show annotations for term's descendants           Sort by:
appendicitis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:16367942 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16367942 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
G PLAU plasminogen activator, urokinase ISO protein:increased expression:appendix RGD PMID:19153874 RGD:6483822 NCBI chr 9:57,452,904...57,459,345
Ensembl chr 9:57,452,761...57,459,286 		JBrowse link
G RET ret proto-oncogene ISO ClinVar Annotator: match by term: Appendicitis ClinVar PMID:11230481 PMID:15320968 PMID:16384843 PMID:16849421 PMID:18058472 More... NCBI chr 9:38,746,088...38,798,773
Ensembl chr 9:38,769,170...38,796,712 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15285
    disease by infectious agent 2055
      Intraabdominal Infections 41
        appendicitis 4
Path 2
Term Annotations click to browse term
  disease 15285
    disease of anatomical entity 14908
      gastrointestinal system disease 6367
        intestinal disease 2861
          cecal disease 11
            appendicitis 4
paths to the root