Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:cocaine abuse
go back to main search page
Accession:DOID:809 term browser browse the term
Definition:A substance abuse that involves the recurring use of cocaine despite negative consequences. (DO)
Synonyms:exact_synonym: cocaine use disorder
 xref: ICD10CM:F14.1;   ICD9CM:305.6
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
cocaine abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase severity ISO RGD PMID:21540357 RGD:401960084 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 severity ISO RGD PMID:21806491 RGD:401794583 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd40lg CD40 ligand severity ISO RGD PMID:21806491 RGD:401794583 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit onset ISO DNA:SNP:exon:rs16969968(human) RGD PMID:32841724 RGD:150530292 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit susceptibility ISO DNA:SNP::rs892413(human) RGD PMID:24675634 RGD:405849277 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit onset ISO DNA:SNP::rs950776(human) RGD PMID:32841724 RGD:150530292 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO
IDA		 protein:increased expression, increased phosphorylation:prefrontal cortex RGD PMID:24205196 PMID:18001273 RGD:401940185, RGD:401959587 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 sexual_dimorphism IEP mRNA:increased expression:brain (rat) RGD PMID:31029877 RGD:401976486 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment ISO RGD PMID:28366798 RGD:405100962 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit IEP associated with alcohol dependence;protein:increased expression: caudate-putamen (rat) RGD PMID:17572394 RGD:401900302 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 sexual_dimorphism ISO
IEP		 protein:increased expression:prefrontal cortex (mouse)
protein:decreased expression:nucleus accumbens (mouse)
protein:increased expression:nucleus accumbens (rat)		 RGD PMID:33497752 PMID:22197517 PMID:11801363 RGD:401976469, RGD:405650197, RGD:405650201 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Hcrt hypocretin neuropeptide precursor treatment ISO RGD PMID:29454841 RGD:401960065 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A IEP protein:decreased expression:dentate gyrus, hypothalamus RGD PMID:9723786 RGD:401900605 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment IEP
IMP		 mRNA:increased expression:orbitofrontal cortex RGD PMID:27733540 PMID:11259563 PMID:20814782 RGD:401900753, RGD:401900755, RGD:401901179 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C treatment IMP RGD PMID:20814782 RGD:401901179 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IDA protein:increased phosphorylation:nucleus accumbens RGD PMID:25522720 RGD:401851063 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IDA protein:increased phosphorylation:nucleus accumbens RGD PMID:25522720 RGD:401851063 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 susceptibility ISO DNA:SNP:intron: (rs4518200) (human) RGD PMID:33242852 RGD:402463938 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IMP RGD PMID:12805318 PMID:9765324 RGD:401976288, RGD:401976376 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Pdyn prodynorphin IEP mRNA:increased expression:caudate putamen
mRNA:increased expression:central amygdaloid nucleus, dentate gyrus of hippocampal formation		 RGD PMID:7694032 PMID:12523490 RGD:401850578, RGD:401850585 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Prl prolactin treatment ISO RGD PMID:17391744 RGD:401960113 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    Chemically-Induced Disorders 1394
      substance-related disorder 713
        substance abuse 235
          cocaine abuse 21
Path 2
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      nervous system disease 14091
        central nervous system disease 12432
          brain disease 11669
            disease of mental health 8321
              substance-related disorder 713
                Cocaine-Related Disorders 145
                  cocaine abuse 21
paths to the root