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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:vipoma
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Accession:DOID:5574 term browser browse the term
Definition:A tumor that secretes VASOACTIVE INTESTINAL PEPTIDE, a neuropeptide that causes VASODILATION; relaxation of smooth muscles; watery DIARRHEA; HYPOKALEMIA; and HYPOCHLORHYDRIA. Vipomas, derived from the pancreatic ISLET CELLS, generally are malignant and can secrete other hormones. In most cases, Vipomas are located in the PANCREAS but can be found in extrapancreatic sites.
Synonyms:exact_synonym: Diarrheogenic Islet Cell Tumor;   Diarrheogenic Tumor;   VIP Secreting Tumor (VIPoma);   VIP-Secreting Tumors (VIPoma);   VIP-secreting tumor;   Vasoactive Intestinal Peptide (VIP) Tumor;   Vasoactive Intestinal Peptide Producing Tumor;   Vipoma Syndrome;   Vipomas;   WDHA;   WDHA syndrome;   WDHA syndromes;   WDHH;   Watery Diarrhea Syndrome;   Watery Diarrhea with Hypokalemic Alkalosis;   Watery Diarrhea, Hypokalemia, and Achlorhydria Syndrome;   diarrheogenic tumors;   malignant vasoactive intestinal peptide-secreting tumor;   malignant vipoma;   vasoactive intestinal peptide-secreting tumor
 primary_id: MESH:D003969
 xref: EFO:1000622;   GARD:5493;   ICDO:8155/3;   NCI:C26749
For additional species annotation, visit the Alliance of Genome Resources.


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vipoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifna1 interferon alpha 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17961653 NCBI chr 4:88,768,324...88,768,893
Ensembl chr 4:88,768,324...88,768,893 		JBrowse link
G Men1 multiple endocrine neoplasia 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17961653 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Sst somatostatin ISO CTD Direct Evidence: therapeutic CTD PMID:2868874 NCBI chr16:23,708,327...23,710,041
Ensembl chr16:23,708,323...23,709,708 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16121
    disease of anatomical entity 15680
      endocrine system disease 6334
        endocrine gland cancer 2449
          neuroendocrine tumor 221
            neuroendocrine carcinoma 101
              vipoma 3
                pancreatic cholera 0
                pancreatic vasoactive intestinal peptide producing tumor 0
                small intestinal vasoactive intestinal peptide producing tumor 0
Path 2
Term Annotations click to browse term
  disease 16121
    disease of cellular proliferation 7571
      Neoplasms by Site 7029
        Nervous System Neoplasms 1622
          nervous system cancer 965
            neuroectodermal tumor 476
              neuroendocrine tumor 221
                islet cell tumor 29
                  pancreatic endocrine carcinoma 14
                    vipoma 3
                      pancreatic cholera 0
                      pancreatic vasoactive intestinal peptide producing tumor 0
                      small intestinal vasoactive intestinal peptide producing tumor 0
paths to the root