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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:thyroid gland medullary carcinoma
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Accession:DOID:3973 term browser browse the term
Definition:A thyroid gland carcinoma that has_material_basis_in parafollicular cells. (DO)
Synonyms:exact_synonym: medullary carcinoma of the thyroid gland;   medullary thyroid cancer (MTC);   thyroid medullary cancer;   thyroid medullary carcinoma;   ultimobranchial thyroid tumor;   ultimobranchial thyroid tumour
 primary_id: MESH:C536914
 xref: NCI:C161006;   NCI:C24170;   NCI:C3879
For additional species annotation, visit the Alliance of Genome Resources.


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thyroid gland medullary carcinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras Kirsten rat sarcoma viral oncogene homolog ISO ClinVar Annotator: match by term: Medullary thyroid gland carcinoma ClinVar PMID:12460918 PMID:15696205 PMID:16361624 PMID:16618717 PMID:17062680 More... NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Ret ret proto-oncogene ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Medullary thyroid carcinoma | ClinVar Annotator: match by term: Medullary thyroid gland carcinoma		 CTD
ClinVar		 PMID:2008030 PMID:2660074 PMID:2904651 PMID:3078962 PMID:7536460 More... NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679 		JBrowse link
familial medullary thyroid carcinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insrr insulin receptor-related receptor ISO ClinVar Annotator: match by term: Familial medullary thyroid carcinoma ClinVar NCBI chr 3:87,704,215...87,723,408
Ensembl chr 3:87,704,258...87,723,408 		JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 ISO ClinVar Annotator: match by term: Familial medullary thyroid carcinoma | ClinVar Annotator: match by term: Thyroid cancer, familial medullary ClinVar PMID:10330344 PMID:10443680 PMID:10861667 PMID:11139246 PMID:11159935 More... NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469 		JBrowse link
G Prlr prolactin receptor IAGP OMIM:155240 MouseDO NCBI chr15:10,177,324...10,349,276
Ensembl chr15:10,177,324...10,349,266 		JBrowse link
G Ret ret proto-oncogene ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Familial medullary thyroid carcinoma | ClinVar Annotator: match by term: Thyroid cancer, familial medullary		 CTD
OMIM
ClinVar		 PMID:2660074 PMID:3078962 PMID:3697657 PMID:7536460 PMID:7595170 More... NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16121
    disease of cellular proliferation 7571
      Neoplasms by Histologic Type 5320
        Glandular and Epithelial Neoplasms 3819
          carcinoma 3279
            thyroid gland carcinoma 105
              thyroid gland medullary carcinoma 5
                familial medullary thyroid carcinoma 4
Path 2
Term Annotations click to browse term
  disease 16121
    disease of cellular proliferation 7571
      Neoplasms by Site 7029
        Nervous System Neoplasms 1622
          nervous system cancer 965
            neuroectodermal tumor 476
              neuroendocrine tumor 221
                neuroendocrine carcinoma 101
                  Medullary Carcinomas 6
                    thyroid gland medullary carcinoma 5
                      familial medullary thyroid carcinoma 4
paths to the root