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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:trachoma
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Accession:DOID:11265 term browser browse the term
Definition:A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea. (DO)
Synonyms:exact_synonym: Egyptian ophthalmia;   active stage trachoma;   trachoma dubium;   trachomas
 primary_id: MESH:D014141
 xref: GARD:10374;   ICD10CM:A71;   ICD10CM:A71.0;   ICD10CM:A71.1;   ICD9CM:076;   ICD9CM:076.0;   ICD9CM:076.1
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
trachoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 susceptibility ISO DNA:SNP:promoter:g.-251A>T (rs4073) (human) RGD PMID:20015396 RGD:150520200 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G IL10 interleukin 10 no_association
severity		 ISO DNA:SNP:promoter:−819T>C, −592A>C (human)
DNA:haplotype: :
DNA:SNP, haplotype:promoter:−1082G>A (human)
protein:increased expression:tear
DNA:SNP:promoter:−1082G>A (human)		 RGD PMID:11023480 PMID:15789056 PMID:17947295 PMID:18628987 RGD:7365037 RGD:7365053 RGD:7365072 RGD:7365085 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL17A interleukin 17A ISO mRNA:increased expression:conjunctiva (human) RGD PMID:21911461 RGD:9068420 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G LOC100982859 class I histocompatibility antigen, Gogo-B*0101 alpha chain ISO DNA:polymorphism:cds:HLA-B*14 (human, Tanzanian) RGD PMID:18824733 RGD:7364877 NCBI chr 6:31,106,562...31,109,933
Ensembl chr 6:31,997,381...32,000,067 		JBrowse link
G TNF tumor necrosis factor ISO DNA:SNP, haplotypes:promoter:−308G>A (human) RGD PMID:17330135 RGD:8548830 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
Trachomatous Trichiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL1A1 collagen type I alpha 1 chain ISO mRNA:decreased expression:tarsal conjunctiva (human) RGD PMID:20375326 RGD:8552676 NCBI chr17:44,274,349...44,291,764
Ensembl chr17:49,150,677...49,166,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15697
    sensory system disease 6706
      eye disease 3393
        corneal disease 223
          trachoma 6
            Trachomatous Trichiasis 1
Path 2
Term Annotations click to browse term
  disease 15697
    disease of anatomical entity 15311
      nervous system disease 13350
        Neurologic Manifestations 9706
          sensory system disease 6706
            eye disease 3393
              Eye Infections 56
                Bacterial Eye Infections 21
                  bacterial conjunctivitis 7
                    trachoma 6
                      Trachomatous Trichiasis 1
paths to the root