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CLINICAL MEASUREMENT - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:hepatic extraction fraction
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Accession:CMO:0003846 term browser browse the term
Definition:This is the fraction of a drug entering the liver from the blood which is irreversibly removed (extracted) during one pass of the blood through the liver. The hepatic extraction fraction (HEF) depends on the hepatic blood flow, uptake into hepatocytes, and enzyme metabolism. HEF can be calculated using deconvolution analysis of the liver using scintigraphic data.
Synonyms:exact_synonym: HEF;   hepatic extraction ratio
 alt_id: CMO:0003842
 xref: PMID:30208622


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Related Phenotype Data for Term "hepatic extraction fraction" (CMO:0003846)

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Clinical Measurements:
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Measurement Methods:
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  clinical measurement 2369
    blood measurement 443
      blood chemistry measurement 426
        blood xenobiotic measurement 0
          blood xenobiotic metabolism measurement 0
            hepatic extraction fraction 0
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