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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester
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Accession:CHEBI:75391 term browser browse the term
Definition:An organic phosphonate that is the trisacetoxymethylester derivative of naphthalene substituted hydroxymethylphosphonic acid. It has been found to inhibit insulin receptor tyrosine kinase activity and insulin stimulated glucose oxidation.
Synonyms:related_synonym: 3-[(acetyloxy)methoxy]-4-(naphthalen-2-yl)-3-oxido-8-oxo-2,5,7-trioxa-3lambda(5)-phosphanon-1-yl acetate;   Formula=C20H23O10P;   HNMPA-(AM)3;   InChI=1S/C20H23O10P/c1-14(21)25-11-28-20(19-9-8-17-6-4-5-7-18(17)10-19)31(24,29-12-26-15(2)22)30-13-27-16(3)23/h4-10,20H,11-13H2,1-3H3;   InChIKey=UQODAZKXEREJLZ-UHFFFAOYSA-N;   SMILES=CC(=O)OCOC(c1ccc2ccccc2c1)P(=O)(OCOC(C)=O)OCOC(C)=O
 xref: LINCS:LSM-6443
 xref_mesh: MESH:C519736
 xref: PMID:2550060;   Reaxys:11322049


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hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins1 insulin 1 multiple interactions EXP hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]] CTD PMID:15172182 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
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  CHEBI ontology 19838
    role 19814
      application 19658
        food additive 16124
          food acidity regulator 11946
            acetic acid 11056
              acetate ester 4057
                hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester 1
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  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      chalcogen 19543
                        oxygen atom 19518
                          oxygen molecular entity 19518
                            hydroxides 19330
                              oxoacid 18765
                                pnictogen oxoacid 13224
                                  phosphorus oxoacid 12428
                                    phosphorus oxoacid derivative 11773
                                      phosphonic acid derivative 2355
                                        phosphonate 184
                                          organic phosphonate 184
                                            hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester 1
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